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Enhancing localization of therapeutic viruses and cells to tumor sitesThe endothelial layer is a barrier through which circulating oncolytic viruses and virus-infected cell carriers must cross to access tumor cells. We propose that addition of vascular binding motifs on...
Lentivirus Infection of Neonatal Dendritic CellsThe central hypothesis to be tested i this application is that differences in the function of antigen-presenting cells, notably dendritic cells (DC's), may be age-dependent. Little direct evidence exists for...
Statistical Analysis of Event Related PotentialsThe millisecond time resolution of event-related potentials (ERPs) gives them a unique advantage in studying brain function, but ERP research is seriously limited by the lack of statistical methods to...
Estradiol's Modulation of Central Auditory ProcessingRecently, Dr. Pinaud's research group demonstrated that the female hormone estrogen controls how auditory signals are processed and interpreted by auditory neurons in the brain. These are exciting findings because...
Curated prostate cancer data for novel and reproducible prognostic modelingProstate cancer is the most commonly diagnosed cancer and the second-leading cause of cancer death in US men. Prostate cancer has a heterogeneous prognosis - many men have an indolent...
Investigating HIF1-alpha Signaling to Identify Predictive Markers and Therapeutic Targets in Desmoid-Type FibromatosisDesmoid-type fibromatosis is a mesenchymal tumor that does not progress to high-grade disease or metastasize. Surgery was the standard treatment for desmoids, but in patients with extensive disease, surgery can...
Leadership, Planning, and EvaluationThe Salk Cancer Center Senior Leadership consists of the Director, Reuben Shaw, the Deputy Director, Geoff Wahl, the Associate Deputy Director, Jan Karlseder, Associate Director of Administration, Suzanne Simon, and...
Molecular Phenotyping and Image-Guidance for Surgical Treatment of High-Risk Prostate Cancer Using Ultrasmall Silica NanoparticlesHigh-risk prostate cancer (PC) is the second most common cause of cancer-related death in men. Improvements in overall survival and long-term morbidity will depend on the ability of the operating...
The postdoctoral training period is nearly essential for all research scientists who aspire to lead a research laboratory in a university or non-profit research center. To characterize the transition of scientists from postdoc to established PI, we previously conducted an analysis of how many postdocs with a NIH-sponsored F32 fellowship went on to become PIs of a R-esearch grant. In 2006, NIH int...
Previously, we calculated the fraction of the R01 grant pool that each institution has obtained in 2013, and how this fraction has changed over time. We now wanted to perform a complementary analysis, determining institutional variability in the length of time that individual PIs are able to maintain NIH grant funding. This analysis would be of interest to university administrators who want to rec...
In our database, for any grant we report "Related Projects" that are renewals of ongoing projects from individual investigators. We wanted to improve this by identifying "Related Projects" more generally in which we group different grants based on the text in the abstract. We analyzed the similarities of 2013 NIH grant abstracts with lengths of at least 100 words (disregarding the public health r...
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